McGill G, Fisher D E
Division of Pediatric Hematology/Oncology, Dana Farber Cancer Institute and Children's Hospital, Boston, MA 02115, USA.
Chem Biol. 1998 Feb;5(2):R29-38. doi: 10.1016/s1074-5521(98)90139-9.
DNA bending has been implicated as an important regulatory mechanism in several processes involving protein-DNA interactions. Various methods for examining intrinsic and protein-induced DNA bending may lead to different conclusions. For the Fos and Jun transcription factors, this has resulted in controversy over whether these factors significantly bend DNA at all.
DNA弯曲已被认为是涉及蛋白质-DNA相互作用的多个过程中的一种重要调控机制。用于检测内在的和蛋白质诱导的DNA弯曲的各种方法可能会得出不同的结论。对于Fos和Jun转录因子而言，这导致了关于这些因子是否真的能使DNA发生显著弯曲的争议。
