γ-氨基丁酸、甘氨酸、印防己毒素和氯化甲基荷包牡丹碱对猫红核脊髓神经元的作用。

Effects of GABA, glycine, picrotoxin and bicuculline methochloride on rubrospinal neurones in cats.

作者信息

Altmann H, Ten Bruggencate G, Pickelmann P, Steinberg R

出版信息

Brain Res. 1976 Jul 30;111(2):337-45. doi: 10.1016/0006-8993(76)90778-2.

Abstract

A microelectrophoretic study was performed of the actions of GABA and glycine, and of their antagonists on rubrospinal neurones. GABA and glycine depressed antidromic and synaptic potentials, hyperpolarized the cell membrane and increased the membrane conductance. GABA was more effective than glycine. Corticorubral IPSPs and the GABA-induced membrane hyperpolarization could be reversed by intracellular application of hyperpolarizing currents. Picrotoxin and bicuculline methochloride antagonized inhibitory GABA actions and the corticorubral IPSP or the corresponding extracellular positive field potential. The results support the hypothesis that GABA is the transmitter of the corticorubral inhibition in the cat.

摘要

对γ-氨基丁酸（GABA）、甘氨酸及其拮抗剂对红核脊髓神经元的作用进行了微电泳研究。GABA和甘氨酸可抑制逆向和突触电位，使细胞膜超极化并增加膜电导。GABA比甘氨酸更有效。通过细胞内施加超极化电流，可逆转皮质红核抑制性突触后电位（IPSPs）和GABA诱导的膜超极化。印防己毒素和氯化甲基荷包牡丹碱可拮抗GABA的抑制作用以及皮质红核IPSP或相应的细胞外正场电位。这些结果支持了GABA是猫皮质红核抑制性神经递质这一假说。