人类IgA2浓度的同种异型相关差异。

Allotype-associated differences in concentrations of human IgA2.

作者信息

Mattila P S, Seppälä I J, Sarvas H, Mäkelä O

机构信息

Department of Otolaryngology, Helsinki University Central Hospital, Finland.

出版信息

Scand J Immunol. 1998 Feb;47(2):106-9. doi: 10.1046/j.1365-3083.1998.00277.x.

DOI:10.1046/j.1365-3083.1998.00277.x

PMID:9496683

Abstract

Concentrations of immunoglobulin (Ig)A2 were determined in 176 Finnish blood donor sera. Their IgA, IgM, IgE, IgG1, IgG2, IgG3 and IgG4 concentrations and Gm allotypes had been determined earlier. The mean concentration of IgA2 was higher in individuals carrying the Gm(ax) allele (0.15 g/l) than in those negative for Gm(x) (0.103 g/l). The difference was statistically significant (P = 0.006). As > or = 70% of IgA was usually IgA1, its concentration could be calculated fairly reliably by subtracting the IgA2 value from the IgA value. The mean IgA1 concentration (2.03 g/l) seemed to be independent of the Gm allotypes.

摘要

对176份芬兰献血者血清中的免疫球蛋白（Ig）A2浓度进行了测定。他们的IgA、IgM、IgE、IgG1、IgG2、IgG3和IgG4浓度以及Gm同种异型此前已测定。携带Gm(ax)等位基因的个体中IgA2的平均浓度（0.15 g/l）高于Gm(x)阴性个体（0.103 g/l）。差异具有统计学意义（P = 0.006）。由于通常>或=70%的IgA为IgA1，其浓度可通过从IgA值中减去IgA2值相当可靠地计算出来。平均IgA1浓度（2.03 g/l）似乎与Gm同种异型无关。