Sapunar J, Quintana L, Ríos L, Tapia N, Villarroel M, Estrada P, Fonseca R, Gudenshwager H
Dpto. de Medicina Interna, Facultad de Medicina, Universidad de la Frontera.
Rev Med Chil. 1997 May;125(5):567-74.
The frequency of diagnosis of primary hyperparathyroidism increased dramatically with the advent of routine serum calcium measurements. The reliability of colorimetric serum calcium measurements is not well known.
To know the frequency of hyper and hypocalcemia in a population of healthy people and the reliability of serum calcium measurements.
Serum calcium was measured in 731 subjects participating in a preventive medical examination, using an automated colorimetric method. Serum albumin was also measured. In 31 randomly chosen serum samples, calcium was also measured by atomic absorption spectrometry. Normal serum calcium ranges were established as the mean +/- 1.34 SD of the sample.
Mean serum calcium was 9 +/- 0.7 mg/dl, serum albumin was 4.3 +/- 0.5 g/dl and albumin corrected calcium levels were 8.7 +/- 0.7 mg/dl. Excluding lipemic sera, colorimetric calcium measurement had a correlation of 0.6 with atomic absorption spectrometry and a reliability of 17.9%. Using the proposed normal ranges (7.3-10.6 mg/dl), the frequency of hypercalcemia and hypocalcemia was 0.14 and 0.4% respectively.
Most subjects found to have hyper or hypocalcemia in this study were asymptomatic.
随着常规血清钙检测的出现，原发性甲状旁腺功能亢进症的诊断频率急剧增加。比色法血清钙检测的可靠性尚不清楚。
了解健康人群中高钙血症和低钙血症的发生率以及血清钙检测的可靠性。
采用自动比色法对731名参加预防性体检的受试者进行血清钙检测。同时检测血清白蛋白。在随机选取的31份血清样本中，还采用原子吸收光谱法检测了钙。正常血清钙范围确定为样本均值±1.34标准差。
血清钙均值为9±0.7mg/dl，血清白蛋白为4.3±0.5g/dl，白蛋白校正钙水平为8.7±0.7mg/dl。排除脂血血清后，比色法钙检测与原子吸收光谱法的相关性为0.6，可靠性为17.9%。使用建议的正常范围（7.3 - 10.6mg/dl），高钙血症和低钙血症的发生率分别为0.14%和0.4%。
本研究中大多数被发现患有高钙血症或低钙血症的受试者无症状。
