Rubins J B, Guzman-Paz M J
Veterans Affairs Medical Center, Minneapolis, MN 55417, USA.
Postgrad Med J. 1997 Dec;73(866):810-2. doi: 10.1136/pgmj.73.866.810.
We report an unusual case of prostatic carcinomatous meningitis and remind clinicians to maintain a high index of suspicion of meningeal involvement when patients with advanced prostatic cancer present with cerebral symptoms, back pain, or neurologic findings. The diagnosis may require repeated cytologic examinations of cerebrospinal fluid, and immunocytochemical stains should be considered to confirm a prostatic source if malignant cells are identified. Androgen ablative therapy may give prolonged remissions, especially in patients with previously untreated tumours.
我们报告了一例罕见的前列腺癌性脑膜炎病例,并提醒临床医生,当晚期前列腺癌患者出现脑部症状、背痛或神经系统体征时,要高度怀疑有脑膜受累。诊断可能需要反复进行脑脊液细胞学检查,如果发现恶性细胞,应考虑进行免疫细胞化学染色以确认前列腺来源。雄激素剥夺疗法可能会带来较长时间的缓解,尤其是对于先前未接受治疗的肿瘤患者。