Dussault J H, Morissette J, Fiset P, Laberge E, Laberge C
Clin Chem. 1976 Aug;22(8):1392-3.
To reduce the number of false-positives in our screening program for neonatal hypothyroidism, we investigated the effect of age, body weight, and interval between sampling and analysis on results for filter paper spot thyroxine determination. The statistical analysis included an analysis of covariance. The age of the infant did not influence the results, the interval influenced them minimally, but weight did require a correction factor of about 0.16 ng/kg below the mean weight. This correction factor should reduce our false-positives from 0.75% to 0.60%. Furthermore, because all hypothyroid infants had results that fell more than 2.8 SD below the geometric mean, we intend to measure thyrotropin concentrations in the blood eluate of all the spots with a thyroxine concentration below that cut-off point.
为减少新生儿甲状腺功能减退症筛查项目中的假阳性数量，我们研究了年龄、体重以及采样与分析之间的时间间隔对滤纸血斑甲状腺素测定结果的影响。统计分析包括协方差分析。婴儿年龄不影响结果，时间间隔对结果影响极小，但体重确实需要一个校正因子，低于平均体重约0.16 ng/kg。这个校正因子应能将我们的假阳性率从0.75%降至0.60%。此外，由于所有甲状腺功能减退的婴儿其结果均比几何平均数低超过2.8个标准差，我们打算对所有甲状腺素浓度低于该临界点的血斑洗脱液测定促甲状腺激素浓度。
