Verbanac J S, Commissaris R L, Pitts D K
Department of Pharmaceutical Sciences, College of Pharmacy & AHP, Wayne State University, Detroit, MI 48202, USA.
Life Sci. 1996;58(3):245-50. doi: 10.1016/0024-3205(95)02282-1.
Extracellular electrophysiological recording techniques were used to study serotonergic dorsal raphe (DRN) neurons in Maudsley Reactive (MR), Maudsley Non-Reactive (MNRA) and Sprague Dawley (SD; reference control strain) rats. No significant differences were observed in the average discharge rates of DRN neurons from SD, MR AND MNRA rats. The sensitivity of DRN neuron somatodendritic 5-HT1A autoreceptors to the inhibitory effects of i.v. 8-OH-DPAT or alpha 1-adrenoceptors to the excitatory effects of iontophoretic phenylephrine did not differ significantly among strains. These findings are discussed in light of the previously reported strain-dependent differences in anxiety-like behavior and noradrenergic locus coeruleus neurons.
采用细胞外电生理记录技术，对莫兹利反应性（MR）、莫兹利非反应性（MNRA）大鼠以及斯普拉格-道利（SD；作为对照参考品系）大鼠的血清素能背缝核（DRN）神经元进行研究。未观察到SD、MR和MNRA大鼠DRN神经元平均放电率存在显著差异。DRN神经元树突体5-羟色胺1A自身受体对静脉注射8-羟基二丙胺（8-OH-DPAT）抑制作用的敏感性，或α1-肾上腺素能受体对离子导入去氧肾上腺素兴奋作用的敏感性，在各品系之间没有显著差异。结合先前报道的品系依赖性焦虑样行为差异和去甲肾上腺素能蓝斑神经元差异，对这些发现进行了讨论。
