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Busulfan versus hydroxyurea in the treatment of polycythemia vera (PV) and essential thrombocythemia (ET).

作者信息

Brodsky I

出版信息

Am J Clin Oncol. 1998 Feb;21(1):105-6. doi: 10.1097/00000421-199802000-00024.

DOI:10.1097/00000421-199802000-00024
PMID:9499248
Abstract
摘要

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Busulfan versus hydroxyurea in the treatment of polycythemia vera (PV) and essential thrombocythemia (ET).白消安与羟基脲治疗真性红细胞增多症(PV)和原发性血小板增多症(ET)的对比
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2
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Evaluation of the need for cytoreduction and its potential carcinogenicity in children and young adults with myeloproliferative neoplasms.评估儿童和青年骨髓增生性肿瘤患者进行细胞减灭术的必要性及其潜在致癌性。
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Leukemogenic risk of hydroxyurea therapy in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis.真性红细胞增多症、原发性血小板增多症和骨髓纤维化伴髓样化生患者接受羟基脲治疗的白血病发生风险。
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Is hydroxyurea leukemogenic in essential thrombocythemia?羟基脲在原发性血小板增多症中会诱发白血病吗?
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Do All Patients With Polycythemia Vera or Essential Thrombocythemia Need Cytoreduction?真性红细胞增多症或原发性血小板增多症患者均需要细胞减少治疗吗?
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Optimal therapy for polycythemia vera and essential thrombocythemia can only be determined by the completion of randomized clinical trials.真性红细胞增多症和原发性血小板增多症的最佳治疗方法只能通过随机临床试验的完成来确定。
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引用本文的文献

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Polycythemia vera: historical oversights, diagnostic details, and therapeutic views.真性红细胞增多症:历史的忽视、诊断的细节和治疗的观点。
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Long-term and low-dose of busulfan is a safe and effective second-line treatment in elderly patients with essential thrombocythemia resistant or intolerant to hydroxyurea.
长期低剂量白消安是对羟基脲耐药或不耐受的老年原发性血小板增多症患者安全有效的二线治疗方法。
Blood Cancer J. 2018 Jun 11;8(6):56. doi: 10.1038/s41408-018-0091-6.
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Polycythemia vera treatment algorithm 2018.真性红细胞增多症治疗算法 2018.
Blood Cancer J. 2018 Jan 10;8(1):3. doi: 10.1038/s41408-017-0042-7.
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Essential thrombocythemia treatment algorithm 2018.2018 年原发性血小板增多症治疗算法
Blood Cancer J. 2018 Jan 10;8(1):2. doi: 10.1038/s41408-017-0041-8.
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Busulfan for the treatment of myeloproliferative neoplasms: the Mayo Clinic experience.白消安治疗骨髓增殖性肿瘤:梅奥诊所的经验
Blood Cancer J. 2016 May 27;6(5):e427. doi: 10.1038/bcj.2016.34.
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Effect of busulfan on JAK2V617F allele burden.
Haematologica. 2014 Mar;99(3):e44. doi: 10.3324/haematol.2013.103051. Epub 2014 Jan 3.
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JAK2V617F allele burden is reduced by busulfan therapy: a new observation using an old drug.白消安治疗可降低JAK2V617F等位基因负荷:一种旧药的新观察结果
Haematologica. 2013 Nov;98(11):e135-7. doi: 10.3324/haematol.2013.087742.
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Haematologica. 2012 Apr;97(4):538-42. doi: 10.3324/haematol.2011.053348. Epub 2011 Nov 18.
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Dehydroalanine analog of glutathione: an electrophilic busulfan metabolite that binds to human glutathione S-transferase A1-1.谷胱甘肽的脱氢丙氨酸类似物:一种与人类谷胱甘肽S-转移酶A1-1结合的亲电白消安代谢产物。
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