Sakurai H, Mitsuhashi N, Ibuki Y, Joshita T, Fukusato T, Niibe H
Department of Radiology and Radiation Oncology, School of Medicine, Gunma University, Maebashi, Japan.
Am J Clin Oncol. 1998 Feb;21(1):39-41. doi: 10.1097/00000421-199802000-00009.
The occurrence of placental metastasis from maternal primitive neuroectodermal tumor (PNET) is extremely rare. A 33-year-old woman at 33 weeks' gestation was admitted to the hospital. She died of the disease on hospital day 28 because the unresectable tumor was located over a wide area of the retroperitoneum. A neonate was delivered by a caesarean section without evidence of disease and has survived to 1 year of age. Pathologically, the tumor consisted of monotonous small round cells with a high nuclear cytoplasmic ratio, including several pseudorosettes and Homer-Wright-type rosettes. On immunohistochemical examination, the tumor cells were positively stained for neuron-specific enolase. Microscopically, the placenta showed intervillous metastasis from the maternal PNET. This case may be the first one of placental metastasis from PNET ever reported in the literature.
母源性原始神经外胚层肿瘤（PNET）发生胎盘转移极为罕见。一名孕33周的33岁女性入院。因无法切除的肿瘤位于腹膜后广泛区域，她于住院第28天死于该疾病。通过剖宫产分娩出一名新生儿，未发现疾病迹象，现已存活至1岁。病理检查显示，肿瘤由核质比高的单一小圆形细胞组成，包括几个假菊形团和霍纳 - 赖特型菊形团。免疫组化检查显示，肿瘤细胞神经元特异性烯醇化酶呈阳性染色。显微镜下，胎盘显示存在来自母体PNET的绒毛间隙转移。该病例可能是文献中首次报道的PNET胎盘转移病例。
