Uguen C, Girard L, Brasseur P, Leblay R
Service de parasitologie et de mycologie, CHU, hôpital Charles-Nicolle, Rouen, France.
Rev Med Interne. 1997;18(12):945-51. doi: 10.1016/s0248-8663(97)80114-2.
Human babesiosis is a rare parasitic infection caused by an haemoprotozoan of genus Babesia, transmitted by tick bites. In Europe, the most severe cases are observed in asplenic patients infected by Babesia divergens. Acute intravascular haemolytic syndrome appears rapidly and is responsible for renal failure and is life threatening. Most of the cases have been reported in France. In contrast, Babesia microti babesiosis observed in the United States are less severe than Babesia divergens cases. The major problem raised by babesiosis is the rapidity of the clinical and biological diagnosis. The currently recommended treatment of severe cases consists of a blood exchange followed by clindamycine intraveine use, 25 mg/kg/d in three treatments, until disappearance of parasitemia. Prophylaxis against tick bites should be recommended for asplenic individuals.
人类巴贝斯虫病是一种由巴贝斯虫属血原虫引起的罕见寄生虫感染,通过蜱虫叮咬传播。在欧洲,最严重的病例见于感染分歧巴贝斯虫的无脾患者。急性血管内溶血综合征迅速出现,可导致肾衰竭,危及生命。大多数病例报告于法国。相比之下,在美国观察到的微小巴贝斯虫病病例不如分歧巴贝斯虫病病例严重。巴贝斯虫病引发的主要问题是临床和生物学诊断的快速性。目前推荐的严重病例治疗方法包括进行换血,随后静脉使用克林霉素,25毫克/千克/天,分三次给药,直至寄生虫血症消失。应建议无脾个体预防蜱虫叮咬。