Bréchignac X, de Wazières B, Desmurs H, Gil H, Berthier S, Levrat R, Dupond J L
Service de médecine interne, hôpital Jean-Minjoz, Besançon, France.
Rev Med Interne. 1997;18(12):967-71. doi: 10.1016/s0248-8663(97)80116-6.
Medical treatment of systemic idiopathic fibrosis is first based on steroid therapy, of which efficacy is well known for nearly 75% of cases of retroperitoneal fibrosis, but les certain for the other localisations of the disease. Studies on the immuno-pathological mechanism of systemic fibrosis have led to immunosuppressive drug use, such as azathioprin, cyclophosphamide and methotrexate. Tamoxifen has been tried because of its efficacy on desmoid tumors and seems to be of great interest. Attention is focused on fibrosing cervicitis which may also be treated with immunosuppressive drugs.
系统性特发性纤维化的医学治疗首先基于类固醇疗法，其对近75%的腹膜后纤维化病例疗效显著，但对该疾病的其他部位疗效不太确定。对系统性纤维化免疫病理机制的研究导致了免疫抑制药物的使用，如硫唑嘌呤、环磷酰胺和甲氨蝶呤。他莫昔芬因其对硬纤维瘤的疗效而被尝试使用，似乎很有前景。人们关注的焦点是纤维性宫颈炎，其也可用免疫抑制药物治疗。
