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抗坏血酸与胆固醇：豚鼠口服不同剂量抗坏血酸对胆固醇转化为胆汁酸的影响。

Ascorbic acid and cholesterol: effect of graded oral intakes on cholesterol conversion to bile acids in guinea-pigs.

作者信息

Hornig D, Weiser H

出版信息

Experientia. 1976 Jun 15;32(6):687-9. doi: 10.1007/BF01919833.

DOI:10.1007/BF01919833
PMID:950005
Abstract

A significant correlation between liver ascorbic acid (AA) and total bile acids or liver bile acids has been established in guinea-pigs by direct determination of the bile acids, confirming an earlier hypothesis. The oxidation of cholesterol to bile acids is dependent on the AA status, but it cannot be further stimulated by AA when the animals are already on an adequate intake of the vitamin. This suggests that AA has a hypocholesterolaemic effect over a limited range of AA status.

摘要

通过直接测定胆汁酸，已在豚鼠中证实肝脏抗坏血酸（AA）与总胆汁酸或肝脏胆汁酸之间存在显著相关性，这证实了先前的一个假设。胆固醇氧化为胆汁酸取决于AA状态，但当动物已摄入足够量的该维生素时，AA不能进一步刺激其氧化。这表明AA在有限的AA状态范围内具有降胆固醇作用。

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Ascorbic acid and cholesterol: effect of graded oral intakes on cholesterol conversion to bile acids in guinea-pigs.抗坏血酸与胆固醇：豚鼠口服不同剂量抗坏血酸对胆固醇转化为胆汁酸的影响。
Experientia. 1976 Jun 15;32(6):687-9. doi: 10.1007/BF01919833.
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本文引用的文献

1
Metabolic studies on scorbutic guinea pigs. 3. Catabolism of [4-C]cholesterol in vivo and in vitro.坏血病豚鼠的代谢研究。3. [4-C]胆固醇在体内和体外的分解代谢。
Biochem J. 1963 Feb;86(2):193-7. doi: 10.1042/bj0860193.
2
The formation of cholic acid from 3alpha, 7alpha-dihydroxycoprostane in the rat.大鼠体内由3α, 7α-二羟基胆烷生成胆酸的过程。
Biochim Biophys Acta. 1956 Mar;19(3):556-7. doi: 10.1016/0006-3002(56)90485-1.
3
The effect of ascorbic acid on the lipid metabolism of guinea-pigs fed an atherogenic diet.抗坏血酸对喂食致动脉粥样化饮食的豚鼠脂质代谢的影响。
Cor Vasa. 1969;11(1):65-73.
4
The effect of ascorbic acid in vitro on the rat ovarian cholesterol side chain cleavage enzyme system.体外抗坏血酸对大鼠卵巢胆固醇侧链裂解酶系统的影响。
Steroids. 1968 Jul;12(1):127-49. doi: 10.1016/s0039-128x(68)80085-6.
5
Metabolic disorders in guinea-pigs with chronic vitamin C hyposaturation.慢性维生素C低饱和度豚鼠的代谢紊乱
Z Versuchstierkd. 1967;9(5):228-35.
6
The effect of ascorbic acid on cholesterolemia in healthy subjects with seasonal deficit of vitamin C.维生素C季节性缺乏的健康受试者中抗坏血酸对胆固醇血症的影响
Nutr Metab. 1970;2(2):76-86. doi: 10.1159/000175278.
7
The effect of chronic hypovitaminosis C on the metabolism of cholesterol and atherogenisis in guinea pigs.慢性维生素C缺乏对豚鼠胆固醇代谢及动脉粥样硬化形成的影响。
J Atheroscler Res. 1969 Nov-Dec;10(3):341-52. doi: 10.1016/s0368-1319(69)80037-2.
8
Lowered cholesterol catabolism in guinea pigs with chronic ascorbic acid deficiency.慢性抗坏血酸缺乏的豚鼠体内胆固醇分解代谢降低。
Am J Clin Nutr. 1971 Oct;24(10):1238-45. doi: 10.1093/ajcn/24.10.1238.
9
Stimulation of (26- 14 C)cholesterol oxidation by ascorbic acid in scorbutic guinea-pigs.抗坏血酸对坏血病豚鼠（26 - 14 C）胆固醇氧化的刺激作用。
Br J Nutr. 1972 Sep;28(2):205-11. doi: 10.1079/bjn19720027.
10
Raised ascorbic acid consumption in cholesterol-fed guinea pigs.在喂食胆固醇的豚鼠中增加抗坏血酸的摄入量。
Int J Vitam Nutr Res. 1972;42(1):72-9.