Kachi T, Takahashi G, Suzuki T, Kimura N, Kaijihara S, Kurushima M, Yamauchi T, Irie T, Kudou H, Saito Y, Hashimoto S, Honma K
Department of Anatomy, Hirosaki University School of Medicine, Japan.
Biol Signals. 1997 Jul-Dec;6(4-6):255-63. doi: 10.1159/000109136.
We aimed to explore whether and how the pineal influences the adrenal medulla, the area postrema and the brain water content; and is influenced by sham pinealectomy (SPX) in its structures and melatonin secretion. Quantitative morphological methods were mainly used in rats and golden hamsters. Experimental results showed: (1) Pineal effects on the A cell system of the adrenal medulla were inhibitory to the synthesis and secretion of epinephrine into the perivascular space and stimulatory to the opioid synthesis, and augmented by SPX. Time-of-day changes were also influenced by SPX and PX. (2) The sizes of a part of the nuclei of nerve and glia cells in the area postrema and the brain water content increased by SPX depending on the presence of the pineal, suggesting the pineal's stimulatory effects on these following SPX. (3) SPX caused morphological changes suggesting an increased activity of pinealocytes. However, corresponding consistent increases in plasma melatonin levels were not seen following SPX. Possible interpretations of these observations were discussed.
我们旨在探究松果体是否以及如何影响肾上腺髓质、最后区和脑含水量；以及松果体切除术假手术（SPX）对其结构和褪黑素分泌的影响。主要在大鼠和金黄仓鼠中采用定量形态学方法。实验结果表明：（1）松果体对肾上腺髓质A细胞系统的作用是抑制肾上腺素向血管周围间隙的合成和分泌，并刺激阿片类物质的合成，且SPX可增强这种作用。一天中的时间变化也受SPX和松果体切除术（PX）的影响。（2）视松果体是否存在，SPX可使最后区神经和胶质细胞部分细胞核的大小以及脑含水量增加，提示松果体切除术后松果体对这些方面具有刺激作用。（3）SPX导致形态学变化，提示松果体细胞活性增加。然而，SPX后血浆褪黑素水平并未相应一致升高。讨论了对这些观察结果的可能解释。
