癫痫遗传学：生物学家的丰富宝藏。

Epilepsy genetics: an abundance of riches for biologists.

作者信息

McNamara J O, Puranam R S

机构信息

Department of Medicine, Duke University Medical Center, 401 Bryan Research Building, Research Drive, Durham, North Carolina 27710, USA.

出版信息

Curr Biol. 1998 Feb 26;8(5):R168-70. doi: 10.1016/s0960-9822(98)70102-2.

DOI:10.1016/s0960-9822(98)70102-2

PMID:9501059

Abstract

Twenty-five genes have been identified in which mutations cause epileptic seizures in mice. The gene for a Na+/H+ exchanger has recently been found to underlie the spontaneous mutant slow wave epilepsy. Studies of such mutants should help elucidate the mechanisms that control neuronal excitability.

摘要

已经鉴定出25个基因，其中的突变会在小鼠中引发癫痫发作。最近发现一种钠氢交换体基因是自发突变型慢波癫痫的基础。对这类突变体的研究应有助于阐明控制神经元兴奋性的机制。