通过T细胞受体激活CD8 + T淋巴细胞会开启CD4基因表达：对HIV发病机制的影响。
Activation of CD8+ T lymphocytes through the T cell receptor turns on CD4 gene expression: implications for HIV pathogenesis.
作者信息
Flamand L, Crowley R W, Lusso P, Colombini-Hatch S, Margolis D M, Gallo R C
机构信息
Institute of Human Virology, University of Maryland Biotechnology Institute at Baltimore, 725 West Lombard Street, Baltimore, MD 21201-1192, USA.
出版信息
Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3111-6. doi: 10.1073/pnas.95.6.3111.
Abstract
T cell activation through the T cell receptor is necessary to achieve a specific and effective immune response. We report here that stimulation of CD8+ T cells through the T cell receptor complex leads to de novo expression of the CD4 antigen on the cell surface that results in susceptibility of CD8+ T cells to HIV infection. In addition, activation of peripheral blood mononuclear cells from HIV-infected individuals results in the appearance of double-positive CD4+/CD8+ T cells, which become infected by endogenous HIV. HIV DNA sequences could be detected in uncultured and sorted mature CD3+CD8+ T cells from HIV+ individuals. These results suggest a new mechanism by which HIV could attack the immune system and may help to explain the CD8+ T cell defects in AIDS patients.
摘要
通过T细胞受体激活T细胞对于实现特异性和有效的免疫反应是必要的。我们在此报告，通过T细胞受体复合物刺激CD8 + T细胞会导致细胞表面CD4抗原的从头表达，从而导致CD8 + T细胞易受HIV感染。此外，来自HIV感染个体的外周血单核细胞的激活导致双阳性CD4 + / CD8 + T细胞的出现，这些细胞会被内源性HIV感染。在来自HIV阳性个体的未培养和分选的成熟CD3 + CD8 + T细胞中可以检测到HIV DNA序列。这些结果提示了一种HIV攻击免疫系统的新机制，并可能有助于解释艾滋病患者中CD8 + T细胞缺陷的原因。
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