基于血氧水平依赖性功能磁共振成像的初级视觉刺激中的性别差异。
Sex differences in blood-oxygenation-level-dependent functional MRI with primary visual stimulation.
作者信息
Levin J M, Ross M H, Mendelson J H, Mello N K, Cohen B M, Renshaw P F
机构信息
Laboratory for Cerebral Blood Flow, Brain Imaging Center, McLean Hospital, Belmont, MA 02178, USA.
出版信息
Am J Psychiatry. 1998 Mar;155(3):434-6. doi: 10.1176/ajp.155.3.434.
OBJECTIVE
The authors evaluated the effect of sex on data derived from activation studies using blood-oxygenation-level-dependent (BOLD) functional magnetic resonance imaging (MRI).
METHOD
Gradient echo-echo planar imaging was used to measure BOLD signal response in the primary visual cortex in response to binocular photic stimulation in 16 healthy, young subjects (eight women and eight men).
RESULTS
BOLD signal response was 38% lower in women than in men, and much of the difference was lateralized to the right hemisphere.
CONCLUSIONS
Lower BOLD signal response in women may reflect a sex difference in the brain's response to a primary visual stimulation or in the physiology underlying BOLD functional MRI signal changes.
目的
作者评估了性别对使用血氧水平依赖（BOLD）功能磁共振成像（MRI）的激活研究所得数据的影响。
方法
采用梯度回波-回波平面成像技术，测量16名健康年轻受试者（8名女性和8名男性）在双眼光刺激下初级视觉皮层的BOLD信号反应。
结果
女性的BOLD信号反应比男性低38%，且大部分差异集中在右半球。
结论
女性较低的BOLD信号反应可能反映了大脑对初级视觉刺激的反应或BOLD功能MRI信号变化背后的生理学方面的性别差异。
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