激动剂对人核受体RARγ的构象适应性 - Suppr

Suppr

超能文献

Conformational adaptation of agonists to the human nuclear receptor RAR gamma.

作者信息

Klaholz B P, Renaud J P, Mitschler A, Zusi C, Chambon P, Gronemeyer H, Moras D

机构信息

Institut de Génétique et de Biologie Moléculaire et Cellulaire, Université Louis Pasteur, Illkirch, France.

出版信息

Nat Struct Biol. 1998 Mar;5(3):199-202. doi: 10.1038/nsb0398-199.

DOI:10.1038/nsb0398-199

PMID:9501913

Abstract

摘要

相似文献

Conformational adaptation of agonists to the human nuclear receptor RAR gamma.激动剂对人核受体RARγ的构象适应性

Nat Struct Biol. 1998 Mar;5(3):199-202. doi: 10.1038/nsb0398-199.

Structure of the epididymal retinoic acid binding protein at 2.1 A resolution.附睾视黄酸结合蛋白的结构，分辨率为2.1埃。

Structure. 1993 Sep 15;1(1):7-18. doi: 10.1016/0969-2126(93)90004-z.

Critical role of the H6-H7 loop in the conformational adaptation of all-trans retinoic acid and synthetic retinoids within the ligand-binding site of RARalpha.H6-H7环在视黄酸受体α（RARα）配体结合位点内全反式维甲酸和合成类视黄醇构象适应中的关键作用。

J Mol Endocrinol. 2000 Jun;24(3):353-64. doi: 10.1677/jme.0.0240353.

Structural basis for isotype selectivity of the human retinoic acid nuclear receptor.人类视黄酸核受体同种型选择性的结构基础。

J Mol Biol. 2000 Sep 8;302(1):155-70. doi: 10.1006/jmbi.2000.4032.

Molecular recognition of agonist ligands by RXRs.视黄酸X受体（RXRs）对激动剂配体的分子识别。

Mol Endocrinol. 2002 May;16(5):987-97. doi: 10.1210/mend.16.5.0823.

Crystal structure of the RAR-gamma ligand-binding domain bound to all-trans retinoic acid.与全反式维甲酸结合的视黄酸受体γ配体结合域的晶体结构。

Nature. 1995 Dec 14;378(6558):681-9. doi: 10.1038/378681a0.

The isolation and characterization of purified heterocomplexes of recombinant retinoic acid receptor and retinoid X receptor ligand binding domains.重组维甲酸受体和维甲酸X受体配体结合域纯化异源复合物的分离与鉴定。

Biochemistry. 1997 May 13;36(19):5669-76. doi: 10.1021/bi9627020.

Synthesis, structure-affinity relationships, and biological activities of ligands binding to retinoic acid receptor subtypes.与维甲酸受体亚型结合的配体的合成、结构-亲和力关系及生物学活性

J Med Chem. 1995 Dec 22;38(26):4993-5006. doi: 10.1021/jm00026a006.

Crystal structures of cellular retinoic acid binding proteins I and II in complex with all-trans-retinoic acid and a synthetic retinoid.细胞视黄酸结合蛋白I和II与全反式视黄酸及一种合成类视黄醇复合物的晶体结构

Structure. 1994 Dec 15;2(12):1241-58. doi: 10.1016/s0969-2126(94)00125-1.

X-ray crystallographic identification of a protein-binding site for both all-trans- and 9-cis-retinoic acid.

Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9223-7. doi: 10.1073/pnas.90.19.9223.

引用本文的文献

Retinoic acid signaling and metabolism in heart failure.心力衰竭中的视黄酸信号传导与代谢

Am J Physiol Heart Circ Physiol. 2025 Apr 1;328(4):H792-H813. doi: 10.1152/ajpheart.00871.2024. Epub 2025 Feb 11.

A pan-family screen of nuclear receptors in immunocytes reveals ligand-dependent inflammasome control.免疫细胞中核受体的全家族筛选揭示了配体依赖性炎性小体控制。

Immunity. 2024 Dec 10;57(12):2737-2754.e12. doi: 10.1016/j.immuni.2024.10.010. Epub 2024 Nov 20.

Molecular Interactions of Selective Agonists and Antagonists with the Retinoic Acid Receptor γ.选择性激动剂和拮抗剂与维甲酸受体 γ 的分子相互作用。

Int J Mol Sci. 2024 Jun 14;25(12):6568. doi: 10.3390/ijms25126568.

Growth modulatory effects of fenretinide encompass keratinocyte terminal differentiation: a favorable outcome for oral squamous cell carcinoma chemoprevention.芬维 A 酯的生长调节作用包括角质细胞的终末分化：口腔鳞状细胞癌化学预防的有利结果。

Carcinogenesis. 2024 Jun 10;45(6):436-449. doi: 10.1093/carcin/bgae022.

Discovery of novel RARα agonists using pharmacophore-based virtual screening, molecular docking, and molecular dynamics simulation studies.基于药效团的虚拟筛选、分子对接和分子动力学模拟研究发现新型 RARα 激动剂。

PLoS One. 2023 Aug 24;18(8):e0289046. doi: 10.1371/journal.pone.0289046. eCollection 2023.

Exploring the interactions of antihistamine with retinoic acid receptor beta (RARB) by molecular dynamics simulations and genome-wide meta-analysis.通过分子动力学模拟和全基因组荟萃分析探索抗组胺药与维甲酸受体β（RARB）的相互作用。

J Mol Graph Model. 2023 Nov;124:108539. doi: 10.1016/j.jmgm.2023.108539. Epub 2023 Jun 9.

Identifying candidate reference chemicals for in vitro testing of the retinoid pathway for predictive developmental toxicity.鉴定候选参比化学物质用于体外测试类视黄醇途径的预测发育毒性。

ALTEX. 2023;40(2):217–236. doi: 10.14573/altex.2202231. Epub 2022 Jun 23.

Cell adhesion signals regulate the nuclear receptor activity.细胞黏附信号调节核受体活性。

Proc Natl Acad Sci U S A. 2019 Dec 3;116(49):24600-24609. doi: 10.1073/pnas.1913346116. Epub 2019 Nov 18.

The molecular basis of the interactions between synthetic retinoic acid analogues and the retinoic acid receptors.合成视黄酸类似物与视黄酸受体之间相互作用的分子基础。

Medchemcomm. 2017 Jan 20;8(3):578-592. doi: 10.1039/c6md00680a. eCollection 2017 Mar 1.

Probing biological activity through structural modelling of ligand-receptor interactions of 2,4-disubstituted thiazole retinoids.通过 2,4-二取代噻唑视黄醇配体-受体相互作用的结构建模探究生物活性。

Bioorg Med Chem. 2018 May 1;26(8):1560-1572. doi: 10.1016/j.bmc.2018.02.002. Epub 2018 Feb 10.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验