[冷冻治疗后前列腺癌的磁共振断层扫描监测：初步结果]
[MR tomographic monitoring of prostate carcinoma after cryotherapy: initial results].
作者信息
Hawighorst H, Dörsam J, Knopp M V, Jugowski W, Schoenberg S O, Wiesel M, Essig M, van Kaick G
机构信息
Abt. Radiologische Diagnostik und Therapie (dkfz), Universität Heidelberg.
出版信息
Rofo. 1998 Jan;168(1):44-8. doi: 10.1055/s-2007-1015180.
PURPOSE
To assess the morphological changes in the prostate gland and adjacent tissue after cryosurgery by high resolution MRI in patients with histological proven prostatic carcinoma.
METHOD
15 patients (mean age 66 years) with histologically proven prostate carcinoma underwent T2- and contrast-enhanced T1-weighted high-resolution MRI examinations with fat suppression. Follow-up MRI with an identical imaging protocol were performed at different time intervals (24-72 h, 2-6, 12, 26-52 weeks).
RESULTS
Mean prostate volume had decreased by 30% in all patients 12-52 weeks after cryosurgery. After cryosurgery, zonal differentiation was lost in all patients with abnormalities in the periprostatic tissue in all patients, and rectal wall thickening in 47% of patients. Cryosurgery-induced changes in the prostate could not be differentiated from tumour recurrence.
CONCLUSION
High resolution MRI allows precise recognition of intraprostatic and adjacent tissue alterations after cryosurgery of prostatic carcinoma. However, reliable detection of tumour recurrence was impossible due to cryosurgically induced signal changes.
目的
通过高分辨率磁共振成像（MRI）评估经组织学证实为前列腺癌的患者在冷冻手术后前列腺及邻近组织的形态学变化。
方法
15例经组织学证实为前列腺癌的患者（平均年龄66岁）接受了T2加权和对比增强T1加权脂肪抑制高分辨率MRI检查。采用相同成像方案在不同时间间隔（24 - 72小时、2 - 6周、12周、26 - 52周）进行随访MRI检查。
结果
在冷冻手术后12 - 52周，所有患者的平均前列腺体积减少了30%。冷冻手术后，所有患者前列腺周围组织均出现异常，前列腺各带区分消失，47%的患者出现直肠壁增厚。冷冻手术引起的前列腺变化无法与肿瘤复发相区分。
结论
高分辨率MRI能够精确识别前列腺癌冷冻手术后前列腺内及邻近组织的改变。然而，由于冷冻手术引起的信号变化，无法可靠地检测肿瘤复发。
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