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Tetrahydronaphthalenic derivatives as new agonist and antagonist ligands for melatonin receptors.

作者信息

Fourmaintraux E, Depreux P, Lesieur D, Guardiola-Lemaître B, Bennejean C, Delagrange P, Howell H E

机构信息

Institut de Chimie Pharmaceutique, Lille, France.

出版信息

Bioorg Med Chem. 1998 Jan;6(1):9-13. doi: 10.1016/s0968-0896(97)00175-2.

DOI:10.1016/s0968-0896(97)00175-2
PMID:9502101
Abstract

Tetrahydronaphthalenic ligands were synthesized and evaluated as melatonin receptor ligands. Biological studies show that the aromaticity of the ring bearing the side chain is not essential for affinity and activity and that replacement of the methoxy group with the bioisostere ethyl which does not offer the possibility of H-bonding, leads to antagonist or forskoline potentiating properties.

摘要

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