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Azole derivatives of 1,4-benzothiazine as antifungal agents.

作者信息

Fringuelli R, Schiaffella F, Bistoni F, Pitzurra L, Vecchiarelli A

机构信息

Istituto di Chimica e Tecnologia del Farmaco, Università di Perugia, Italy.

出版信息

Bioorg Med Chem. 1998 Jan;6(1):103-8. doi: 10.1016/s0968-0896(97)10016-5.

DOI:10.1016/s0968-0896(97)10016-5
PMID:9502109
Abstract

A series of azole derivatives of 1,4-benzothiazine 7-14 was synthesized and evaluated for the in vitro and in vivo activity against Candida albicans. Secondary alcohol 10 and its ether derivative 13 showed very good efficacy against systemic candidiasis in a murine experimental model.

摘要

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