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半月瓣的自体心包重建术。

Autologous pericardial reconstruction of semilunar valves.

作者信息

Love J W

机构信息

CardioMend LLC, Santa Barbara, California, USA.

出版信息

J Heart Valve Dis. 1998 Jan;7(1):40-7.

PMID:9502138
Abstract

BACKGROUND AND AIMS OF THE STUDY

Previous methods for reconstructing semilunar valves have been characterized by lack of precision and reproducibility and, with one exception, the use of unsuitable biomaterial. A new method combines precision with simplicity to reconstruct aortic and pulmonary valves with lightly tanned autologous tissue supported by the annulus of the native valve. Essential components include sizing based on distance between adjacent commissures, cutting a seamless, size-specific trefoil-shaped pattern of tissue with a tricuspid orifice, temporary mounting of the pattern on disposable formers, and suturing with continuous or interrupted monofilament suture to join the autologous tissue pattern with the valve annulus.

METHODS

The tissue pattern is cut and mounted on forming devices that enable the implanting surgeon to visualize the orientation clearly, and perform repair accurately and rapidly. One, two or three leaflets can be reconstructed. The forming and cutting devices are discarded when reconstruction is complete. Diseased valves can be reconstructed in no more time than is required for replacement with a prosthesis of any type. Advantages of the method include preservation of full effective orifice area, lack of need for any foreign body other than the sutures used for reconstruction, and the use of non-immunogenic autologous tissue known to be durable and resistant to calcific degeneration. Contraindications include heavily calcified annulus that cannot be satisfactorily debrided, bicuspid anatomy, or a significantly asymmetric annulus.

RESULTS

Pulmonary valve reconstructions have been performed in four juvenile sheep by this method. Three animals survived five months; there was one operative death due to non-valve related causes.

CONCLUSIONS

Semilunar valve reconstruction with autologous tissue can be simple, precise, and reproducible.

摘要

研究背景与目的

以往重建半月瓣的方法存在缺乏精确性和可重复性的问题,并且除一种方法外,均使用了不合适的生物材料。一种新方法将精确性与简易性相结合,利用天然瓣膜瓣环支撑的轻度鞣制自体组织重建主动脉瓣和肺动脉瓣。基本步骤包括根据相邻瓣叶交界处之间的距离确定尺寸,切割具有三尖瓣口的无缝、特定尺寸的三叶形组织图案,将该图案临时固定在一次性成型器上,以及用连续或间断单丝缝线缝合,将自体组织图案与瓣膜瓣环连接起来。

方法

切割组织图案并将其固定在成型装置上,使植入手术医生能够清晰地看到其方向,并准确、快速地进行修复。可以重建一瓣、两瓣或三瓣。重建完成后,成型和切割装置即被丢弃。重建病变瓣膜所需的时间不会超过使用任何类型假体进行置换所需的时间。该方法的优点包括保留完整的有效瓣口面积,除了用于重建的缝线外无需任何异物,以及使用已知耐用且抗钙化变性的非免疫原性自体组织。禁忌症包括无法令人满意地清创的严重钙化瓣环、二叶式解剖结构或明显不对称的瓣环。

结果

已通过该方法对四只幼年绵羊进行了肺动脉瓣重建。三只动物存活了五个月;有一例手术死亡,原因与瓣膜无关。

结论

用自体组织重建半月瓣可以简单、精确且可重复。

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