McGill H C
Southwest Foundation for Biomedical Research, San Antonio, TX 78245-0549, USA.
Curr Opin Lipidol. 1998 Feb;9(1):23-7. doi: 10.1097/00041433-199802000-00006.
Fat-modified diets for children are controversial. Infant nutrition imprints adult lipid metabolism in animals, but evidence is not available for humans. Three intervention trials to reduce total fat, saturated fat and cholesterol intake in children showed small effects on lipid intakes and on serum lipids, but no adverse effects. Serum lipoproteins are associated with coronary artery raised lesions in young adults. Although modifying dietary intakes of children and adolescents appears difficult, changes sufficient to lower plasma cholesterol levels would retard the progression of atherosclerosis and would be safe.
儿童脂肪改良饮食存在争议。婴儿营养会影响动物成年后的脂质代谢，但尚无人类相关证据。三项旨在降低儿童总脂肪、饱和脂肪和胆固醇摄入量的干预试验对脂质摄入量和血脂的影响较小，但无不良影响。血清脂蛋白与年轻成年人冠状动脉病变增加有关。虽然改变儿童和青少年的饮食摄入量似乎很困难，但足以降低血浆胆固醇水平的改变将延缓动脉粥样硬化的进展，并且是安全的。
