Fandeur T, Chalvet W
Laboratoire de Parasitologie Moleculaire, Institut Pasteur de Guyane, Cayenne, French Guiana.
Am J Trop Med Hyg. 1998 Feb;58(2):225-31. doi: 10.4269/ajtmh.1998.58.225.
Variant- and strain-specific immunity to malaria in Saimiri monkeys infected with homologous O and R variants of the Palo Alto strain (FUPSP) of Plasmodium falciparum or by various heterologous divergent strains were studied. Following homologous reinfections, the primary immune response in monkeys was effective only against the same variant type but not against the other variant, which differed only by antigens exposed at the surface of the infected red blood cell. In contrast, after two successive inoculations with a single variant type, a variant transcending immunity developed to both O and R parasite populations. The immunity against FUPSP in monkeys repeatedly infected with various combinations of heterologous strains, including Sal I, Tanzania, Camp, FUPCP, FCH4, FVO, and FUPCDC parasites was less effective, resulting at best in protecting the monkey against fulminating infection. However, in several cases, previous or concomitant heterologous infections modified the course of virulent infection by FUPSP parasites, indicating a significant degree of cross-protection between the strains. Therefore, in this model, while variant- and strain-specific antigens are important components of acquired immunity to malaria, the monkey immune response to infection transcends phenotypic antigenic variation and strain diversity.
研究了感染恶性疟原虫帕洛阿尔托株（FUPSP）同源O和R变体或各种异源不同菌株的松鼠猴对疟疾的变体和菌株特异性免疫。同源再感染后，猴子的初次免疫反应仅对相同变体类型有效，而对仅因感染红细胞表面暴露的抗原不同的其他变体无效。相比之下，在连续两次接种单一变体类型后，产生了对O和R寄生虫群体的超越变体的免疫力。在多次感染包括Sal I、坦桑尼亚、Camp、FUPCP、FCH4、FVO和FUPCDC寄生虫等各种异源菌株组合的猴子中，对FUPSP的免疫效果较差，充其量只能保护猴子免受暴发性感染。然而，在一些情况下，先前或同时发生的异源感染改变了FUPSP寄生虫的毒性感染进程，表明菌株之间存在显著程度的交叉保护。因此，在这个模型中，虽然变体和菌株特异性抗原是获得性疟疾免疫的重要组成部分，但猴子对感染的免疫反应超越了表型抗原变异和菌株多样性。
