Xue Y, Aye N N, Hashimoto K
Department of Pharmacology, Yamanashi Medical University, Japan.
Nihon Yakurigaku Zasshi. 1997 Oct;110 Suppl 1:165P-170P. doi: 10.1254/fpj.110.supplement_165.
DHA-Ascorbic acid (DHA-As), a new derivative of docosahexaenoic acid (DHA) was tested for its possible antiarrhythmic effects on coronary artery ligation/reperfusion arrhythmias in rat hearts, and adrenaline-induced arrhythmias in canine hearts. DHA-As (3 mg/kg i.v.) did not change the total duration of VT, and tended to suppress the incidence of VT, VF and mortality of reperfusion in rat hearts. The heart rate, QT90 and systolic blood pressure did not change, and the diastolic blood pressure was decreased by DHA-As in the rat hearts. DHA-As significantly decreased the arrhythmic ratio only at two time points (14 and 15 min after injection), and also decreased the heart rate and mean blood pressure in canine hearts. In conclusion, DHA-As tended to suppress the reperfusion-induced arrhythmias in rat hearts. However, the change was not statistically significant. In addition, DHA-As has a weak suppressing effect on adrenaline-induced arrhythmia.
二十二碳六烯酸 - 抗坏血酸（DHA - As）是二十二碳六烯酸（DHA）的一种新衍生物，对其在大鼠心脏冠状动脉结扎/再灌注心律失常以及犬心脏肾上腺素诱导的心律失常方面的潜在抗心律失常作用进行了测试。DHA - As（静脉注射3mg/kg）并未改变室性心动过速（VT）的总持续时间，且有抑制大鼠心脏VT、室颤（VF）发生率及再灌注死亡率的趋势。大鼠心脏的心率、QT90及收缩压未改变，而舒张压因DHA - As降低。DHA - As仅在两个时间点（注射后14和15分钟）显著降低心律失常发生率，并且也降低了犬心脏的心率和平均血压。总之，DHA - As有抑制大鼠心脏再灌注诱导心律失常的趋势。然而，这种变化无统计学意义。此外，DHA - As对肾上腺素诱导的心律失常有较弱的抑制作用。
