Shilkina N P, Baranov A A, Varshavskaia A A, Makarushin A A, Nasonov E L, Panchenko K I, Nikolaev A G
Ter Arkh. 1997;69(12):15-8.
Concentration of von Willebrand's factor antigen (WFAg) was measured by solid phase enzyme immunoassay in the blood serum of 17 female patients (mean age 56.7 +/- 12.1 years) with primary Sjogren's syndrome (PSS) lasting, on the average, 4.1 +/- 1.5 years. Mean WFAg level in patients with PSS was equal to 2.56 +/- 1.4 IU/ml and exceeded significantly that of donors' (1.06 +/- 0.34, p < 0.001). In 9(53%) of 17 patients WFAg concentration was higher than normal (> 2.1 IU/ml). WFAg mean levels and frequency of its elevation did not differ significantly in patients with chronic parotitis, enlarged salivary glands, arthralgia/arthritis, lymphadenopathy, lung lesions, polyneuropathy and patients free of the above symptoms. In patients with myalgia, Raynaud's syndrome, skin vasculitis and vascular diseases WFAg concentrations were higher than in patients without them. There was no significant correlation between WFAg level and ESR, concentration of C-reactive protein, presence of rheumatoid and antinuclear factors.
采用固相酶免疫分析法检测了17例原发性干燥综合征（PSS）女性患者（平均年龄56.7±12.1岁）血清中血管性血友病因子抗原（WFAg）的浓度，这些患者病程平均为4.1±1.5年。PSS患者的WFAg平均水平为2.56±1.4 IU/ml，显著高于献血者（1.06±0.34，p<0.001）。17例患者中有9例（53%）的WFAg浓度高于正常水平（>2.1 IU/ml）。慢性腮腺炎、唾液腺肿大、关节痛/关节炎、淋巴结病、肺部病变、多发性神经病患者与无上述症状的患者相比，WFAg平均水平及其升高频率无显著差异。有肌痛、雷诺综合征、皮肤血管炎和血管疾病的患者WFAg浓度高于无这些疾病的患者。WFAg水平与血沉、C反应蛋白浓度、类风湿因子和抗核因子的存在无显著相关性。
