Alimova E V, Martsevich S Iu, Kutishenko N P, Metelitsa V I
Ter Arkh. 1997;69(12):37-40.
Potential tolerance to isosorbide dinitrate (ID) and molsidomine (M) was studied in 18 ischemic heart disease (IHD) patients with stable angina of effort entered in a double blind cross-over trial. Each drug was administered for 3 weeks 4 times a day in individual effective dose. Single doses of ID and M were similar by effectiveness, but after 3 weeks of regular intake their efficacy fell, ID becoming less potent than M. For ID, tolerance after long-term intake manifested in 7 out of 18 patients, for M--in 5 out of 18. Complete tolerance was registered in 3 of 18 and 1 of 18 patients, respectively. Thus, tolerance is possible for the two drugs, but for M it is less pronounced.
在一项双盲交叉试验中，对18例患有劳力性稳定型心绞痛的缺血性心脏病（IHD）患者进行了硝酸异山梨酯（ID）和吗多明（M）潜在耐受性的研究。每种药物均以个体有效剂量每日4次给药，持续3周。单剂量的ID和M在疗效上相似，但在规律服用3周后，它们的疗效下降，ID的效力变得低于M。对于ID，18例患者中有7例出现长期服用后的耐受性，对于M，18例中有5例出现。分别有18例中的3例和18例中的1例出现完全耐受性。因此，这两种药物都可能产生耐受性，但M的耐受性不太明显。
