[Nocturnal enuresis as a manifestation of autocoidosis].

The study entered 30 children with nocturnal enuresis and 20 healthy controls aged 6-15 years. The enuretic children had a higher night diuresis and free water reabsorption; there was an increase in nocturnal excretion of sodium, calcium and magnesium ions. Before going to bed the patients received diclofenac-sodium. Inhibition of cyclooxygenase and decrease of prostaglandin production led to normalization of diuresis and natriuresis, elimination of nocturnal enuresis episodes. The evidence has been obtained that nocturnal enuresis is accompanied by an increased production of autocoids in the thick ascending Henle loop and, as a result, of an increase in saluresis and diuresis. It is suggested that there is a form of nocturnal diuresis which depends on a local hyperproduction of autocoids. The problem of autocoids role in the internal medicine is discussed.