Itoh H, Ushijima S
Department of Psychiatry, Jikei University School of Medicine.
Nihon Rinsho. 1998 Feb;56(2):312-7.
The desynchronaization between sleep-wakefulness rhythm and other biological rhythms such as rectal temperature rhythm and melatonin rhythm is the most unique characteristics for human circadian rhythms. Based on the findings of desynchronaization, a multi-oscillator hypothesis has been advanced for the human circadian clock. Three kind of the hypotheses such as Wever, Kronauer and two-process model were introduced in this article. According to the multi-oscillator hypothesis, one clock regulates rectal temperature and melatonin rhythm and another clock regulates sleep-wake rhythm. There are a few differences between the two different kind of circadian rhythms. For example, the oscillator mechanism which regulates the rectal temperature and the melatonin rhythm are reseted directly by the bright light, but the sleep-wake rhythm is entrained by the bright light through an internal coupling to the former mechanism. And it is also recognized that the length and the structure of sleep are depended strongly on the phase of biological clock which regulates the rectal temperature rhythm.
睡眠-觉醒节律与其他生物节律(如直肠温度节律和褪黑素节律)之间的不同步是人类昼夜节律最独特的特征。基于不同步的研究结果,人们提出了一种关于人类生物钟的多振荡器假说。本文介绍了三种假说,如韦弗假说、克罗瑙尔假说和双过程模型。根据多振荡器假说,一个时钟调节直肠温度和褪黑素节律,另一个时钟调节睡眠-觉醒节律。这两种不同的昼夜节律之间存在一些差异。例如,调节直肠温度和褪黑素节律的振荡器机制直接由强光重置,但睡眠-觉醒节律则通过与前一种机制的内部耦合被强光所调节。并且人们也认识到,睡眠的时长和结构强烈依赖于调节直肠温度节律的生物钟相位。