Hashizume Y
Omuta City General Hospital.
Nihon Rinsho. 1998 Feb;56(2):510-4.
The various hypnotics are currently available. Today benzodiazepine (BZ) derivatives are most used, but non-benzodiazepines (non-BZ), are being used. BZs and non-BZs are classified four groups by means of pharmacokinetics, (1) ultra-rapidly elimination hypnotics, (2) rapidly elimination hypnotics, (3) relatively slow elimination hypnotics and (4) slow elimination hypnotics. BZs modulate gamma-aminobutyric acid (GABA)-ergic transmission, and specific receptors exist in the brain. GABA is the most abundant inhibitory neuro-transmitter in the central nervous system. BZs alter sleep by binding receptor-GABA receptor-chloride channel.
目前有各种各样的催眠药。如今苯二氮䓬（BZ）衍生物使用最为广泛，但非苯二氮䓬类（非BZ）药物也在被使用。BZ类和非BZ类药物通过药代动力学被分为四类：（1）超快速消除催眠药，（2）快速消除催眠药，（3）相对缓慢消除催眠药和（4）缓慢消除催眠药。BZ类药物调节γ-氨基丁酸（GABA）能传递，大脑中存在特定受体。GABA是中枢神经系统中最丰富的抑制性神经递质。BZ类药物通过与受体-GABA受体-氯离子通道结合来改变睡眠。
