Dorman J
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA.
Gac Med Mex. 1997;133 Suppl 1:151-4.
The WHO DiaMond Molecular IDDM Epidemiology Sub-Project is testing the hypothesis that population variation in the frequency of high-risk HLA-DQ alleles is a primary determinant of the global patterns of IDDM incidence. Data are currently available for 16 populations, and reveal significant variations in the frequencies of HLA-DQA1 and DQB1 alleles among the case and the control groups. However, DQA1 x Arg-(52) and DQB1 x non-Asp-57 (ND) were consistent and independent markers of IDDM susceptibility in all populations, except Japan. Individuals who carried only DQA1 x R and DQB1 x ND alleles had an IDDM risk similar to that observed for first degree relatives of affected individuals (3%-5%). Such information is essential for the development of clinical strategies or disease prevention approaches for the general population or individuals at high-risk. Thus, the DiaMond Molecular Epidemiology Sub-Project provides an excellent model that can be followed to assess the impact of new genetic discoveries on medicine and public health practice for diabetes and other chronic diseases.
世界卫生组织糖尿病分子IDDM流行病学子项目正在验证一个假设，即高危HLA - DQ等位基因频率的人群差异是全球IDDM发病率模式的主要决定因素。目前已有16个人群的数据，这些数据显示病例组和对照组中HLA - DQA1和DQB1等位基因频率存在显著差异。然而，除日本外，DQA1 x Arg-(52)和DQB1 x非Asp-57（ND）在所有人群中都是IDDM易感性的一致且独立的标志物。仅携带DQA1 x R和DQB1 x ND等位基因的个体患IDDM的风险与受影响个体的一级亲属所观察到的风险相似（3%-5%）。此类信息对于为普通人群或高危个体制定临床策略或疾病预防方法至关重要。因此，糖尿病分子流行病学子项目提供了一个出色的模型，可依此评估新的基因发现对糖尿病及其他慢性病的医学和公共卫生实践的影响。
