Friberg D, Gazelius B, Lindblad L E, Nordlander B
Department of Otorhinolaryngology, Söder Hospital, Karolinska Institute, Stockholm, Sweden.
Laryngoscope. 1998 Mar;108(3):431-6. doi: 10.1097/00005537-199803000-00022.
A local disturbance in the afferent nerves involved in the reflexogenic dilation of the upper airways (UAs) could contribute to the increased collapsibility seen in patients with obstructive sleep apnea (OSA). Laser Doppler perfusion monitoring, combined with electrical stimulation, is a method for investigating the afferent nerve regulation of the microcirculation. It was used in the mucosa of the soft palate in 35 patients with various degrees of UA obstruction and in 13 control subjects, all nonsmoking men. In a majority of snorers and patients with mild OSA, stimulation induced an exaggerated vasodilation, compared with controls. In contrast, in patients with severe OSA, the vasodilation was significantly reduced, compared with controls. These signs of disturbances in the microcirculation support the hypothesis of a local progressive afferent nerve lesion in heavy snorers with or without OSA.
上气道（UAs）反射性扩张所涉及的传入神经局部紊乱，可能是导致阻塞性睡眠呼吸暂停（OSA）患者气道塌陷增加的原因。激光多普勒血流监测结合电刺激，是一种研究微循环传入神经调节的方法。该方法应用于35例不同程度UA阻塞患者及13名对照者（均为不吸烟男性）的软腭黏膜。与对照组相比，大多数打鼾者和轻度OSA患者在刺激后会出现过度的血管舒张。相反，与对照组相比，重度OSA患者的血管舒张明显减弱。这些微循环紊乱的迹象支持了这样一种假说，即无论有无OSA，重度打鼾者存在局部进行性传入神经病变。
