Kornalijnslijper J E, Kemp B, Bevers M M, van Oord H A, Taverne M A
Department of Herd Health and Reproduction, Faculty of Veterinary Medicine, Utrecht University, Netherlands.
Anim Reprod Sci. 1997 Dec 5;49(2-3):169-78. doi: 10.1016/s0378-4320(97)00077-8.
Jugular plasma prolactin (PRL), growth hormone (GH) and progesterone (P4) levels were estimated in goats under three different conditions with prolonged luteal function (P4 > or = 1 ng/ml): pseudopregnant animals (n = 4), goats hysterectomized during early pregnancy (n = 4) and does with normal pregnancy (n = 4). Mean duration (+/- S.E.M.) of luteal phases were 189 +/- 20, 171 +/- 10, and 147 +/- 2 days in the three groups, respectively. Until day 120, mean PRL levels were below 150 ng/ml in each group. After day 120 of the luteal phase, PRL concentrations were significantly higher than before, but continued to increase up to 800 ng/ml only in pregnant animals around parturition. Mean GH levels varied between 2 and 3 ng/ml in animals of each group during the luteal phase. Only after parturition, a significant elevation occurred. P4 levels in pseudopregnant animals were significantly lower than in the other two groups between days 10 and 55, and showed a gradual but continuous decline towards the end of the luteal phase. After hysterectomy of early pregnant animals, P4 concentrations decreased to levels measured in pseudopregnant animals but were significantly higher again as compared to pseudopregnant animals between days 121 and 150. It is concluded that a pseudopregnant condition, characterized by intrauterine fluid accumulation, is not related to increased plasma PRL and GH concentrations. The low and gradually decreasing plasma progesterone levels in the pseudopregnant animals probably reflect the absence of a luteotrophic stimulus by the conceptus. The progesterone profile in the animals that were hysterectomized during early pregnancy suggests that the corpora lutea of these does have been permanently changed by the presence of the conceptus during the first weeks of the luteal phase.
在黄体功能延长（孕酮（P4）≥1 ng/ml）的三种不同条件下，对山羊的颈静脉血浆催乳素（PRL）、生长激素（GH）和孕酮（P4）水平进行了评估：假孕动物（n = 4）、妊娠早期子宫切除的山羊（n = 4）和正常妊娠的母羊（n = 4）。三组黄体期的平均持续时间（±标准误）分别为189±20天、171±10天和147±2天。在第120天之前，每组的平均PRL水平均低于150 ng/ml。在黄体期第120天之后，PRL浓度显著高于之前，但仅在分娩前后的怀孕动物中持续升高至800 ng/ml。在黄体期，每组动物的平均GH水平在2至3 ng/ml之间变化。仅在分娩后，GH水平才显著升高。在第10至55天期间，假孕动物的P4水平显著低于其他两组，并且在黄体期末期呈现逐渐但持续的下降。早期怀孕动物子宫切除后，P4浓度降至假孕动物测得的水平，但在第121至150天期间与假孕动物相比又显著更高。得出的结论是，以子宫内液体蓄积为特征的假孕状态与血浆PRL和GH浓度升高无关。假孕动物中血浆孕酮水平低且逐渐下降，可能反映了没有来自孕体的黄体营养刺激。早期怀孕时子宫切除的动物的孕酮谱表明，这些母羊的黄体在黄体期的最初几周因孕体的存在而发生了永久性改变。
