Salvi R J, Chen L, Trautwein P, Powers N, Shero M
Dept. Communicative Disorders & Sciences, SUNY University at Buffalo, NY 14214, USA.
Scand Audiol Suppl. 1998;48:7-14.
Chickens were exposed to an intense pure tone that destroyed the hair cells and tectorial membrane in a crescent shaped patch along the abneural edge of the basilar papilla. During the following weeks, when the hair cells and tectorial membrane were regenerating, psychophysical and electrophysiological measures were obtained to assess the time course and degree of recovery. Immediately after the exposure, the behavioral thresholds were elevated 30-40 dB and auditory temporal integration was greatly reduced; however, both measures fully recovered by 28 days post-exposure. In addition, tone-on-tone masking patterns recovered to normal. Immediately after the exposure, the thresholds of single cochlear ganglion neurons were elevated more than 30 dB, tuning curves were broader than normal, two-tone rate suppression (TTRS) boundary slopes were shallower than normal and spontaneous activity was reduced. Threshold and spontaneous discharge rate fully recovered after the exposure. Tuning and TTRS also recovered significantly in most neurons; however, some units with characteristic frequencies (CFs) near the exposure frequency showed abnormal tuning and TTRS suppression. The regeneration of the hair cells and lower honeycomb layer of the tectorial membrane is associated with considerable recovery of function; however, the incomplete recovery of tuning and TTRS in some neurons may be linked to the incomplete regeneration of the tectorial membrane.
将鸡暴露于一种强烈的纯音下，该纯音会破坏沿基底乳头神经外边缘呈新月形区域内的毛细胞和盖膜。在接下来的几周内，当毛细胞和盖膜再生时，获取了心理物理学和电生理学测量数据，以评估恢复的时间进程和程度。暴露后立即出现行为阈值升高30 - 40分贝，听觉时间整合显著降低；然而，这两项测量指标在暴露后28天均完全恢复。此外，音对音掩蔽模式也恢复正常。暴露后立即出现单个耳蜗神经节神经元的阈值升高超过30分贝，调谐曲线比正常情况更宽，双音速率抑制（TTRS）边界斜率比正常情况更平缓，并且自发放电减少。暴露后阈值和自发放电率完全恢复。大多数神经元的调谐和TTRS也显著恢复；然而，一些特征频率（CF）接近暴露频率的单元显示出异常的调谐和TTRS抑制。毛细胞和盖膜下部蜂窝层的再生与功能的显著恢复相关；然而，一些神经元中调谐和TTRS的不完全恢复可能与盖膜的不完全再生有关。
