Kuchmerovskaia T M, Donchenko G V, Klimenko A P, Chichkovskaia G V, Pakirbaeva L V, Kozitskiĭ Z Ia, Efimov A S
A.V. Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine.
Ukr Biokhim Zh (1978). 1997 May-Jun;69(3):77-82.
Streptozotocin-induced diabetes in rats is accompanied by development of diabetic complications such as neuropathies. It was shown that aldose reductase inhibitors (A1-1576, sorbinil and unithiol) administration partially normalized not only polyol pathway. Aldose reductase inhibitors partially restored Na+, K(+)-ATP-ase activity in sciatic nerve of diabetic rats and redox state of nicotinamide adenine dinucleotides. The sorbitol level increases in streptozotocin-diabetic rats as compared to control. Administration of aldose reductase inhibitors to diabetic rats is accompanied by partial reduction of sorbitol level in sciatic nerve. The results obtained confirm the important role of a dose reductase inhibitors, as antidiabetic drugs, in the improvement of diabetic neuropathy.
链脲佐菌素诱导的大鼠糖尿病伴有糖尿病并发症如神经病变的发展。研究表明，给予醛糖还原酶抑制剂（A1-1576、索比尼尔和二巯基丙醇）不仅能使多元醇途径部分恢复正常。醛糖还原酶抑制剂能部分恢复糖尿病大鼠坐骨神经中Na+、K(+)-ATP酶活性以及烟酰胺腺嘌呤二核苷酸的氧化还原状态。与对照组相比，链脲佐菌素诱导的糖尿病大鼠山梨醇水平升高。给糖尿病大鼠服用醛糖还原酶抑制剂后，坐骨神经中山梨醇水平会部分降低。所得结果证实了醛糖还原酶抑制剂作为抗糖尿病药物在改善糖尿病神经病变方面的重要作用。
