蔗鼠（Thryonomys swinderianus）炎症标志物的演变：与兔（Oryctolagus cuniculus）和大鼠（Rattus norvegicus）的比较。

Evolution of grass-cutter (Thryonomys swinderianus) inflammation markers: comparison with rabbit (Oryctolagus cuniculus) and rat (Rattus norvegicus).

作者信息

Ahissou H, Lebreton de Vonne T, Esnard F, Mouray H

机构信息

Laboratoire de Biochimie FAST/UNB, Cotonou, République du Benin.

出版信息

Comp Biochem Physiol A Physiol. 1997 Dec;118(4):1309-12. doi: 10.1016/s0300-9629(97)00244-2.

DOI:10.1016/s0300-9629(97)00244-2

PMID:9505435

Abstract

An inflammatory reaction was induced in grass-cutters (Thryonomys swinderianus) by injecting turpentine. The changes in the plasma haptoglobin, fibrinogen, alpha 2 macroglobulin and immunoglobulin G was followed for 23 days by immunonephelometry. The results were compared to rat and rabbit. They showed that (a) the inflammatory reaction is delayed in the grass-cutter compared to rats and rabbits; (b) the concentration of haptoglobin increases less than in rat and rabbit; (c) the fibrinogen concentration is very low in the grass-cutter, despite hypercoagulability of blood; (d) the changes in the plasma alpha 2-macroglobulin in the grass-cutter seems to be comparable to that of rabbit alpha 1 macroglobulin in amplitude and in its slow return to the initial concentration; and (e) fibrinogen and haptoglobin are suitable markers for grass-cutter inflammation monitoring.

摘要

通过注射松节油在蔗鼠（非洲巨鼠）中诱导炎症反应。采用免疫比浊法对血浆中触珠蛋白、纤维蛋白原、α2巨球蛋白和免疫球蛋白G的变化进行了23天的跟踪观察。将结果与大鼠和兔子的结果进行比较。结果显示：（a）与大鼠和兔子相比，蔗鼠的炎症反应延迟；（b）触珠蛋白浓度的增加低于大鼠和兔子；（c）尽管血液具有高凝性，但蔗鼠的纤维蛋白原浓度非常低；（d）蔗鼠血浆α2巨球蛋白的变化在幅度和缓慢恢复到初始浓度方面似乎与兔子α1巨球蛋白的变化相当；（e）纤维蛋白原和触珠蛋白是监测蔗鼠炎症的合适标志物。