阿托伐他汀不改变华法林的抗凝活性。
Atorvastatin does not alter the anticoagulant activity of warfarin.
作者信息
Stern R, Abel R, Gibson G L, Besserer J
机构信息
Department of Clinical Pharmacology, Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Company, Ann Arbor, Michigan, USA.
出版信息
J Clin Pharmacol. 1997 Nov;37(11):1062-4. doi: 10.1002/j.1552-4604.1997.tb04288.x.
Abstract
Twelve patients chronically maintained on warfarin were administered 80 mg atorvastatin for 2 weeks. Mean prothrombin times decreased slightly, but only for the first few days of the two-week treatment period. Thus atorvastatin had no consistent effect on the anticoagulant activity of warfarin and adjustment in warfarin dosing should not be necessary.
摘要
12名长期服用华法林的患者接受了为期2周的80毫克阿托伐他汀治疗。平均凝血酶原时间略有下降，但仅在为期两周的治疗期的头几天出现这种情况。因此，阿托伐他汀对华法林的抗凝活性没有持续影响，无需调整华法林的剂量。
Zotero 插件