Everson M P, Lemak D G, McDuffie D S, Koopman W J, McGhee J R, Beagley K W
Department of Medicine, The University of Alabama at Birmingham, 35294-0006, USA.
J Interferon Cytokine Res. 1998 Feb;18(2):103-15. doi: 10.1089/jir.1998.18.103.
The role of antigen-presenting cells (APC) in regulating the balance of T helper type 1 (Th1) and T helper type 2 (Th2) responses and cytokine production is unclear. Dendritic cells (DC), the most potent APC for naive T cell activation, were found to regulate Th1 and Th2 cytokine profiles in a manner dependent on their tissue of origin. Using whole tissues or purified cell mixtures, spleen (systemic) DC were found to induce mainly Th1 cytokines, and Peyer's patch (mucosal) DC were found to induce predominantly Th2 cytokines. Spleen DC induced high levels of interferon-gamma (IFN-gamma) or interleukin-2 (IL-2) or both, and Peyer's patch DC induced IL-4 or IL-6 or both in spleen and Peyer's patch T cells, allogeneic mixed leukocyte reactions, or antigen-specific Th0 clones. These data suggest that the tissue of origin of DC has a significant impact on subsequent T cell development.
抗原呈递细胞（APC）在调节1型辅助性T细胞（Th1）和2型辅助性T细胞（Th2）反应平衡以及细胞因子产生方面的作用尚不清楚。树突状细胞（DC）是激活初始T细胞最有效的APC，研究发现其以依赖于起源组织的方式调节Th1和Th2细胞因子谱。使用全组织或纯化的细胞混合物，发现脾脏（全身）DC主要诱导Th1细胞因子，而派尔集合淋巴结（黏膜）DC主要诱导Th2细胞因子。脾脏DC在脾脏和派尔集合淋巴结T细胞、同种异体混合淋巴细胞反应或抗原特异性Th0克隆中诱导高水平的干扰素-γ（IFN-γ）或白细胞介素-2（IL-2）或两者，而派尔集合淋巴结DC诱导IL-4或IL-6或两者。这些数据表明，DC的起源组织对随后的T细胞发育有重大影响。
