Saiz A, Graus F, Valldeoriola F, Valls-Solé J, Tolosa E
Service of Neurology, Department of Medicine, Hospital Clínic i Provincial, University of Barcelona, Spain.
Ann Neurol. 1998 Mar;43(3):400-3. doi: 10.1002/ana.410430322.
We report on 2 patients who presented stiffness and spasms similar to those of stiff-man syndrome (SMS) that were limited to one leg for up to 11 years. Patients had serum glutamic acid decarboxylase (GAD) autoantibodies in high titer, clinical evidence of organ-specific autoimmunity, and electromyographic pattern of continuous motor unit activity with abnormally enhanced exteroceptive reflexes. The clinical and immunological profile suggests that this disorder may be a focal form of SMS.
我们报告了2例患者，他们表现出与僵人综合征（SMS）相似的僵硬和痉挛，且局限于一条腿长达11年。患者血清谷氨酸脱羧酶（GAD）自身抗体呈高滴度，有器官特异性自身免疫的临床证据，以及连续运动单位活动伴异常增强的外感受性反射的肌电图模式。临床和免疫学特征表明，这种疾病可能是SMS的一种局灶性形式。
