Wieczorowska-Tobis K, Korybalska K, Polubinska A, Radkowski M, Breborowicz A, Oreopoulos D G
Department of Pathophysiology, University Medical School, Poznan, Poland.
Int J Artif Organs. 1997 Dec;20(12):673-7.
This study was designed to analyze the complex morphologic and functional effects of dialysis solutions on peritoneum in a rat model on chronic peritoneal dialysis. Peritoneal catheters were inserted into 10 male, Wistar rats and the animals were dialyzed twice daily for 4 weeks with 4.25% Dianeal. During the study we observed two opposite effects: healing of the peritoneum after catheter implantation--decreased cell count in dialysate, decreased permeability of the peritoneum to glucose and total protein, increased volume of drained dialysate; and damage to the membrane due to its exposure to peritoneal dialysis solution--increased hyaluronic acid levels in dialysate, a tendency of the peritoneum to thicken when compared to non-dialyzed animals. Our rat model of CAPD may be used for quantitative and qualitative assessment of the effects of peritoneal dialysis solution on the peritoneum during chronic dialysis.
本研究旨在分析透析液对慢性腹膜透析大鼠模型腹膜的复杂形态学和功能影响。将腹膜导管插入10只雄性Wistar大鼠体内，用4.25%的 Dianeal 溶液对动物进行每日两次、为期4周的透析。在研究过程中，我们观察到两种相反的效应：导管植入后腹膜的愈合——透析液中细胞计数减少、腹膜对葡萄糖和总蛋白的通透性降低、引流透析液体积增加；以及由于腹膜暴露于腹膜透析液而导致的膜损伤——透析液中透明质酸水平升高，与未透析动物相比，腹膜有增厚的趋势。我们的持续性非卧床腹膜透析大鼠模型可用于定量和定性评估慢性透析期间腹膜透析液对腹膜的影响。
