Rekvig O P, Andreassen K, Moens U
Scand J Rheumatol. 1998;27(1):1-6. doi: 10.1080/030097498441100.
In 1997, the discovery of autoantibodies reactive with DNA celebrates its fortieth anniversary. Over these 4 decades, hardly any other single spontaneously produced antibody population has been subjected to such a wide scientific interest both from a basic immunological as well as from a clinical point of view. From the time of their first description, myths and enigmas regarding their biological origin have dominated the scene. Only during the last few years results have been obtained that have justified new conceptual frameworks for the understanding of the molecular bases for their production, as well as for their pathophysiological potential in systemic lupus erythematosus (SLE). Central, newly obtained experimental and clinical results that have profoundly improved our understanding of the origin and biology of anti-DNA antibodies will be presented and discussed below.
1997年，与DNA发生反应的自身抗体的发现迎来了其四十周年纪念。在这40年里，几乎没有任何其他单一的自发产生的抗体群体从基础免疫学以及临床角度受到如此广泛的科学关注。从它们首次被描述之时起，关于其生物学起源的谜团就一直占据着主导地位。直到最近几年，才获得了一些成果，这些成果为理解其产生的分子基础以及它们在系统性红斑狼疮（SLE）中的病理生理潜能提供了新的概念框架。下面将介绍并讨论一些新获得的核心实验和临床结果，这些结果极大地增进了我们对抗DNA抗体的起源和生物学特性的理解。
