Methyl palmoxirate increases eating behavior and brain Fos-like immunoreactivity in rats.

Administration of methyl palmoxirate (MP), an inhibitor of fatty acid oxidation, stimulates eating behavior in rats. Fos immunohistochemistry was used to determine neural pathways that may play a role in the eating response to MP. The number of cells showing Fos-like immunoreactivity (Fos-li) was quantified by computerized image analysis. MP treatment, at a dose that increased food intake (10 mg/kg, p.o.), induced Fos expression in the nucleus of the solitary tract, area postrema, lateral parabrachial nucleus, central lateral nucleus of the amygdala, dorsal lateral bed nucleus of the stria terminalis, and the paraventricular nucleus of the hypothalamus. The results suggest that MP activates an afferent pathway projecting from the hindbrain to the forebrain, which may be involved in the eating response after MP treatment.