Baba T, Schneewind O
Dept of Microbiology & Immunology, UCLA School of Medicine 90095, USA.
Trends Microbiol. 1998 Feb;6(2):66-71. doi: 10.1016/S0966-842X(97)01196-7.
Bacteria have devised ingenious enzymatic machinery to synthesize antibiotic molecules (bacteriocins) for their continuous warfare with other microorganisms. Synthesis and export of these toxic compounds are coordinated to ensure the proper extracellular activation of bacteriocin toxicity. In designing future antibiotics, some of the tricks used by bacteriocins might be exploited for the synthesis of novel compounds.
细菌已经设计出巧妙的酶机制来合成抗生素分子(细菌素),以便与其他微生物持续作战。这些有毒化合物的合成和输出是协调进行的,以确保细菌素毒性在细胞外得到适当激活。在设计未来的抗生素时,细菌素所使用的一些技巧可能会被用于合成新型化合物。