Baltz R H
DowElanco, Indianapolis, IN 46268, USA.
Trends Microbiol. 1998 Feb;6(2):76-83. doi: 10.1016/S0966-842X(97)01161-X.
The genetic manipulation of Streptomyces species has been facilitated by the development of versatile cloning vectors, robust gene transfer systems and transposable elements. These molecular genetic tools have been used to construct antibiotic-producing strains with improved properties and recombinants for the production of hybrid glycopeptide and macrolide antibiotics, novel anthelminthic agents and novel cytotoxic anthracyclines.
多功能克隆载体、强大的基因转移系统和转座元件的发展推动了链霉菌属物种的基因操作。这些分子遗传学工具已被用于构建具有改良特性的抗生素生产菌株以及用于生产杂合糖肽和大环内酯类抗生素、新型驱虫剂和新型细胞毒性蒽环类药物的重组体。
