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Cultured rat sensory neurones express functional tachykinin receptor subtypes 1, 2 and 3.

作者信息

Brechenmacher C, Larmet Y, Feltz P, Rodeau J L

机构信息

Laboratoire de Neurobiologie Cellulaire, CNRS UPR 9009, Strasbourg, France.

出版信息

Neurosci Lett. 1998 Jan 30;241(2-3):159-62. doi: 10.1016/s0304-3940(98)00045-7.

DOI:10.1016/s0304-3940(98)00045-7
PMID:9507945
Abstract

The neuropeptide substance P (SP) is known to play a key role in peripheral nociceptive processes. We investigated the in vitro pharmacological characteristics of functional tachykinin receptors expressed in dorsal root ganglia (DRG) sensory neurones by analysing intracellular free calcium concentration changes induced after stimulation by SP or specific tachykinin agonists. We observed that about 37% of the tested neurones were responsive to either SP or an NK1-, NK2- or NK3-specific agonist. Tachykinin-responsive neurones had a small soma diameter (<20 microm) and were sensitive to capsaicin. These results suggest the presence of NK1, NK2 and NK3 receptors in noxious sensory neurones.

摘要

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