Fisher W R, Zech L A, Stacpoole P W
Department of Medicine, University of Florida College of Medicine, Gainesville 32610-0226, USA.
J Lipid Res. 1998 Feb;39(2):388-401.
The effect on apolipoprotein B kinetics of a diet enriched in either fish oil or safflower oil was investigated in five hypertriglyceridemic (HTG), non-insulin-dependent diabetic subjects. The fish oil diet decreased plasma triglycerides and VLDL-apoB but increased LDL-apoB and LDL-cholesterol. Total plasma apoB concentration did not change, nor did the increased VLDL-apoB secretion present in these HTG subjects, which, accompanied by impaired lipolysis, accounted for their elevated VLDL. The fish oil-induced fall in VLDL resulted from a decrease in secretion without a change in residence time. The IDL fraction, which also contained small VLDL, was the primary site for the secretion of apoB particles in the HTG subjects. On the fish oil diet there was a further, compensatory increase in the secretion of these lipoproteins such that the transport of apoB in IDL remained the same, as did its mass. In the HTG subjects the major portion of IDL lipoproteins was catabolized, with LDL-apoB production comprising the lesser quantity. On the fish oil diet, a shift in the channeling of the lipoprotein output from IDL resulted in a decrease in the catabolic pathway and an increase in conversion to LDL. As the residence time of LDL did not change, this increased input gave rise to the larger mass of LDL-apoB seen in these hypertriglyceridemic subjects when receiving a fish oil diet.
在五名高甘油三酯血症（HTG）、非胰岛素依赖型糖尿病患者中，研究了富含鱼油或红花油的饮食对载脂蛋白B动力学的影响。鱼油饮食降低了血浆甘油三酯和极低密度脂蛋白载脂蛋白B（VLDL-apoB），但增加了低密度脂蛋白载脂蛋白B（LDL-apoB）和低密度脂蛋白胆固醇。血浆总载脂蛋白B浓度没有变化，这些HTG患者中存在的VLDL-apoB分泌增加也没有改变，这与脂解受损一起导致了他们VLDL的升高。鱼油导致的VLDL下降是由于分泌减少而停留时间没有变化。中间密度脂蛋白（IDL）部分，其中也包含小的VLDL，是HTG患者中载脂蛋白B颗粒分泌的主要部位。在鱼油饮食中，这些脂蛋白的分泌进一步代偿性增加，使得IDL中载脂蛋白B的转运及其质量保持不变。在HTG患者中，IDL脂蛋白的主要部分被分解代谢，产生低密度脂蛋白载脂蛋白B的量较少。在鱼油饮食中，脂蛋白输出从IDL的通道发生改变，导致分解代谢途径减少，转化为LDL增加。由于LDL的停留时间没有变化，这种增加的输入导致这些高甘油三酯血症患者在接受鱼油饮食时出现更大质量的LDL-apoB。
