Anderson H A, Maisel R H, Cantrell R W
Laryngoscope. 1976 Aug;86(8):1251-7. doi: 10.1288/00005537-197608000-00016.
Isolated laryngeal lymphoma is a rare occurrence. We found a total of 14 previously reported cases. These plus ouradditional case are reviewed in order to make recommendations for diagnosis, therapy,a nd follow-up. Histologic classification and clinical staging of lymphomas have limited usefulness, because the tumor can change cell type during the clinical course of the disease. Once histologic proof of the tumor exists, adequate evaluation consists of physical examination to detect adenopathy elsewhere, bone marrow biopsy, urinalysis, blood uric acid levels, liver biopsy, and liver and kidney function tests. The search must continue in the chest by X-ray, the retroperitoneal nodes by lymphangiography and the abdomonal visera by contrast radiography. Radiation therapy is the best initial treatment for isolated laryngeal lymphoma. If the tumor does not respond to irradiation, then operation to remove the lesion is required. This tumor has a tendency to recur at distant sites many years later. As with all cancer patients life-long follow-up is required.
孤立性喉淋巴瘤较为罕见。我们共发现14例既往报道的病例。现将这些病例加上我们的新增病例进行回顾，以便对诊断、治疗及随访提出建议。淋巴瘤的组织学分类和临床分期作用有限，因为肿瘤在疾病临床过程中可能会改变细胞类型。一旦有肿瘤的组织学证据，充分的评估包括体格检查以发现其他部位的淋巴结肿大、骨髓活检、尿液分析、血尿酸水平、肝活检以及肝肾功能检查。必须继续通过胸部X线检查排查胸部情况，通过淋巴管造影检查腹膜后淋巴结，通过造影检查腹部脏器。放射治疗是孤立性喉淋巴瘤的最佳初始治疗方法。如果肿瘤对放疗无反应，则需要手术切除病变。这种肿瘤多年后有在远处部位复发的倾向。与所有癌症患者一样，需要进行终身随访。
