Waxman D, Peck J R
Centre for the Study of Evolution, University of Sussex, Brighton, UK.
Science. 1998 Feb 20;279(5354):1210-3.
A mathematical model is presented in which a single mutation can affect multiple phenotypic characters, each of which is subject to stabilizing selection. A wide range of mutations is allowed, including ones that produce extremely small phenotypic changes. The analysis shows that, when three or more characters are affected by each mutation, a single optimal genetic sequence may become common. This result provides a hypothesis to explain the low levels of variation and low rates of substitution that are observed at some loci.
本文提出了一个数学模型，其中单个突变可影响多个表型特征，每个表型特征都受到稳定选择。允许存在广泛的突变，包括那些产生极小表型变化的突变。分析表明，当每个突变影响三个或更多特征时，单一的最优基因序列可能会变得常见。这一结果为解释在某些基因座观察到的低变异水平和低替换率提供了一个假设。
