Kimbrough R D
Institute for Evaluating Health Risks, Washington, DC 20006, USA.
Teratog Carcinog Mutagen. 1997;17(4-5):265-73.
The half-lives and tissue distribution of chlorinated dibenzodioxins and dibenzofurans in humans are reviewed. An attempt is made to correlate adverse effects observed in humans such as chloracne, Yusho, Yucheng, and Seveso with tissue levels. No causal inferences should be made in the Ranch Hand studies because TCDD serum levels are slightly higher in older persons and in persons who have diseases related to their lipid metabolism and their age. These differences cannot be used in the context of a dose-response relationship but should be used in the context of variations in the distribution of PCDD and PCDF levels within different subpopulations. Based on these observations in humans, TEF values for mixtures of PCDD and PCDF are poor predictors of human risk.
本文综述了人类体内氯代二苯并二恶英和二苯并呋喃的半衰期及组织分布情况。文中尝试将人类所观察到的不良反应（如氯痤疮、油症、玉成病和塞韦索事故）与组织水平进行关联。在“牧场工人”研究中不应做出因果推断，因为在老年人以及患有与脂质代谢和年龄相关疾病的人群中，血清中的2,3,7,8-四氯二苯并对二恶英（TCDD）水平略高。这些差异不能用于剂量反应关系的研究，但应结合不同亚人群中多氯二苯并二恶英（PCDD）和多氯二苯并呋喃（PCDF）水平分布的差异来考虑。基于对人类的这些观察结果，PCDD和PCDF混合物的毒性当量因子（TEF）值并不能很好地预测人类风险。
