Gugushe T S, de Wet F A, Rojas-Silva O
Department of Community Dentistry, Faculty of Dentistry, Medical University of Southern Africa, Medunsa.
J Dent Assoc S Afr. 1994 May;49(5):209-12.
The purpose of this study was to assess the efficacy of a dentifrice containing 1 per cent chlorhexidine gluconate at reducing plaque formation and gingival inflammation over a 12 week period. The effects of the test toothpaste were compared with control and conventional dentifrices in a randomised double-blind clinical trial of parallel design. Following baseline examination at which gingival and plaque indices (GI and PI) were measured, 156 primary school children were assigned to one of three groups that were matched for age, gender, GI and PI. After plaque control instruction the pupils were requested to use the dentifrice twice daily. After 6 and 12 week intervals the PI and GI were reassessed. There was no significant difference in GI between groups. The PI was significantly lower (p < 0.002) after use of the chlorhexidine containing dentifrice compared with the other two products.
本研究的目的是评估一种含1%葡萄糖酸氯己定的牙膏在12周内减少牙菌斑形成和牙龈炎症的效果。在一项平行设计的随机双盲临床试验中，将测试牙膏的效果与对照牙膏和传统牙膏进行了比较。在进行基线检查（测量牙龈和牙菌斑指数，即GI和PI）后，156名小学生被分为三组，这三组在年龄、性别、GI和PI方面相互匹配。在进行牙菌斑控制指导后，要求学生每天使用两次牙膏。在6周和12周后重新评估PI和GI。各组之间的GI没有显著差异。与其他两种产品相比，使用含氯己定牙膏后PI显著更低（p < 0.002）。
