Gibson A T
Jessop Hospital for Women, Sheffield.
Br J Hosp Med. 1997;58(8):381-4, 397.
Deficiency of pulmonary surfactant is responsible for a substantial proportion of the mortality and morbidity in infants born prematurely. Surfactant replacement therapy has been extensively investigated and has become a central part of neonatal intensive care in the UK over the last 3 years. Evidence for the efficacy of this treatment is provided as is a discussion of the different surfactant preparations available and different protocols for administration.
肺表面活性物质缺乏是导致早产婴儿大量死亡和发病的重要原因。在过去三年里，表面活性物质替代疗法已得到广泛研究，并成为英国新生儿重症监护的核心组成部分。文中提供了该疗法有效性的证据，以及对现有不同表面活性物质制剂和不同给药方案的讨论。
